Â
ïŒèªå翻蚳ïŒ
2024/09/04
äžççãªç·æ¥äºæ ã®å±éïŒæ¥æ¬ã¯æ¥æãããã«ã»ã²ã€ããæ¿èªããèªå·±è€è£œåmRNAã¯ã¯ãã³ãçºå£²ããŸã
ãã«ã»ã²ã€ãã®ã¯ã¯ãã³äº€æãšãã極æªééãªèšç»ããåã³å éããã€ã€ããã
2024/01/19
ã²ã€ããã¯ã¯ãã³å€æŽèšç»ãæãã
Â
圌ã¯ãäžççãªmRNAã¯ã¯ãã³ã®åãçµã¿ã掻çšããããã«ããã¯ããŠã³ãã¯ã¯ãã³ã®çŸ©ååãæ¯æããåŸãä»ã§ã¯äžçã®äººã ã«ãããé·ãæéãšããåºãã«ãã¬ããžãã§ã¯ã¯ãã³ãæ¥çš®ããããšãæãã§ããŸããããã¯ã人å ã§å¢å¹ ããããã«èšèšãããæ°ããã¯ã©ã¹ã®ãèªå·±è€è£œãã¯ã¯ãã³ã®ææãªãã®ã§ãã
2024幎10æãŸã§ã«ãæ¥æ¬ã¯ãã®ç©è°ãéžãæ°åCOVID-19ã¯ã¯ãã³ãèªå·±è€è£œã¯ã¯ãã³ããæåã«å°å
¥ããåœãšãªããŸããKostaive(ARCT-154)ãšããŠç¥ããããã®ã¯ã¯ãã³ã¯ãäœå
ã§è€è£œããèªå·±å¢å¹
åmRNAã¯ã¯ãã³(saRNA)ã§ãå€æ¥ã¿ã³ãã¯è³ªãšGENESã®ã³ããŒãäœæããæäœå¿çã®é·æã³ãŒãåãšé·ææäœãè¡ããŸãã
2024/09/01
æ¥ææ¥æ¬ã§çºå£²äºå®ã®èªå·±è€è£œã¯ã¯ãã³ã¯ãäžççãªçœå®³ãããããå¯èœæ§ããããŸã
Â
æ°ããsaRNAã¯ã¯ãã³ã¯ãå人ã®å
ç«å¿çãé·æçã«æäœããããã®éºäŒåãè€è£œããŸã
ãã®æ°ããã¯ã©ã¹ã®saRNAã¯ã¯ãã³ã¯ãåŸæ¥ã®æå/ã¢ãžã¥ãã³ãããŒã¹ã®ã¯ã¯ãã³ã¢ãã«ãè¶
ããŠãmRNAã¯ã¯ãã³ã®ããã»ã¹ãããã«äžæ©é²ããã¹ãã€ã¯ã¿ã³ãã¯è³ªãã³ãŒãããRNAã®è€è£œãšåæã«å¿
èŠãªGENESãçµ±åããŸããmRNAã¯ã¯ãã³ãmRNAãåç¶ããéããå
ç«åå¿ã«å¿
èŠãªã¹ãã€ã¯ã¿ã³ãã¯è³ªããç£çããªãã®ã«å¯ŸããsaRNAã¯ã¯ãã³ã¯ãèªèº«ãšãããã³ãŒãããã¿ã³ãã¯è³ªã®ã³ããŒãäœæããããã«æäœãããŠããŸãããã®ãçç©åŠçå°å·æ©ãã¯ãçè«çã«ã¯ã¯ã¯ãã³ã®ååšãå¢å¹
ããäœå
ã§ãã®å¹æãç¡éã«å¢æ®ãããããšãã§ããŸãã
ãããããã®saRNAã¯ã¯ãã³ãmRNAã¯ã¯ãã³ã®ãããªãã®ã§ããã°ã圌ããåŒãèµ·ããå¿èãè³ã®æå·ã¯ç¶ç¶ããæ¢ããããªããã®ãšãªããèŠãã¿ãšæ©ææ»äº¡ã®åå ãšãªãã§ããããããã«æªãããšã«ãã¯ã¯ãã³æ¥çš®åŸæ°ã¶æãå Žåã«ãã£ãŠã¯æ°å¹Žã«ããã£ãŠæåºããã»ã¹ãä¿èšŒãããã¯ã¯ãã³æ¥çš®ãåããå人ã¯çç©æŠäºãåºããããã®ææ¯å·¥å Žã«å€ãããŸãã
Â
èªå·±è€è£œã¯ã¯ãã³ã¯ããããä»ã®çç©çš®ã«äžççãªãªã¹ã¯ããããã
æ¥æ¬æ¿åºã¯ãææ°ã®åºåçã§ããCOVID-19ã«å¯Ÿããæå¹æ§ãå®èšŒããäžé£ã®åœèšåºè©ŠéšãçµãŠã2023幎11æã«Kostaiveãæ¿èªããŸããã
æ°ããã¯ã¯ãã³æè¡ã®èåãªæ¹è©å®¶ã§ãããããšã«ã»ãã¬ã»å士ã¯ããã®æ°æè¡ã®æœåšçãªäžççãªãªã¹ã¯ãç¹ã«ãããã®å€æ¥ã¿ã³ãã¯è³ªãéºäŒåã®æåºããã»ã¹ãžã®é·æã«ãããè·æ¥çæé²ã«é¢ããŠãæ·±å»ãªæžå¿µãè¡šæããŠããŸããé·ç¬å士ã«ãããšããããã®ã¯ã¯ãã³ã«ãã£ãŠå°å ¥ããã人工éºäŒåã¯ã人éã®å®¿äž»ãè¶ ããŠåºãããç°å¢ãæ±æããä»ã®äººã ãä»ã®çš®ã«æªåœ±é¿ãäžããå¯èœæ§ããããŸãã圌ã¯ãããããäžççãªçœå®³ãã«ã€ãªããå¯èœæ§ããããšèŠåããç¹ã«ãããã®å€æ¥éºäŒåãçæ ç³»ã«äŸµå ¥ããçš®éã§ææãçºçããå Žåã«é¡èã«ãªãå¯èœæ§ããããšèŠåããŸããã
ãã¬ã»æ°ã¯ãã¯ã¯ãã³ãã£ã³ããŒã³ãå§ãŸãã°ããåå¢ããã¯ã¯ãã³ãä»äººã®äœå ã«å ¥ããã®ãé²ãããšã¯äºå®äžäžå¯èœã«ãªããšèŠåããŠããŸãã
saRNAã¯ã¯ãã³ã®åºç€ãšãªãã¢ã«ãã¡ãŠã€ã«ã¹ã¯ãçš®ã®å£ãè¶ããŠå®¿äž»ã®å€ã§çãæ®ãèœåã§ç¥ãããŠããŸãããã®ç¹æ§ã¯ãã¯ã¯ãã³ã®éºäŒç©è³ªãä»ã®ãŠã€ã«ã¹ãšåçµåããããèãªã©ã®æè«ãä»ããŠåºãã£ããããæããåŒãèµ·ãããå°ã蟌ãã®åãçµã¿ãããã«è€éã«ããŸããããããã£æ¯é¡ãéãé³¥é¡ã倧ååºä¹³é¡ãç¡èæ€åç©ãªã©ãããŸããŸãªèæ€åç©ã«ææãã32çš®é¡ã®ã¢ã«ãã¡ãŠã€ã«ã¹çš®ããããŸãããããã®ãŠã€ã«ã¹ã¯ãçš®ç¹ç°çã§ããå Žåãããã°ãè€æ°ã®å®¿äž»ã«ææããå¯èœæ§ãããå ŽåããããŸããèã¯ãèæ€åç©ãšäººéãå«ãç°ãªãçš®éã®ææã®äž»èŠãªæ段ã§ãã
ä»å¹Žåããäžçä¿å¥æ©é¢(WHO)ã®ãã³ãããã¯æ¡çŽãšmRNAã¯ã¯ãã³ãšã¬ããªã³ã³ã¯ã¯ãã³ã®å°å ¥ã«å察ããæ°å人ã®æ¥æ¬äººãæè°æŽ»åãè¡ããŸããã埳åå åæ°ãåšæ¥ååœå€§äœ¿é€šã«å®ãŠãæžç°¡ã«ã¯ããããã®æžå¿µãåæ ãããŠãããã¬ããªã³ã³ã¯ã¯ãã³ã®éºäŒåã®æ¡æ£ãé²ãããã«ã¯ãå³æã®é¿é£ãšå ¥åœçŠæ¢ãå¿ èŠã§ãããšç€ºåããŠããŸããæžç°¡ã¯ããããã®éºäŒåãç°å¢ã«å°å ¥ããããšããã®æ¡æ£ãå¶åŸ¡ããããšã¯ã»ãŒäžå¯èœã«ãªãå¯èœæ§ããããšèŠåããŠããŸãã
ãã®ãã©ã³ã¹ãã¥ãŒãããºã ã®æ¬¡ã®æ®µéã¯ãå ç«ç³»ãå¶åŸ¡ããããã®æ°ããéºäŒåãå°å ¥ãã人éã®çç©å µåšã®æŽèµ°è£œé ãå¯èœã«ããã§ãããã
Â
æ°ããèªå·±è€è£œsa-mRNAã¯ã¯ãã³ã倧éçç£ã«æ¿èªãããŸãã -- äºå®ã¯ããã³ã»ãã«ãã³ããšéèŠ
Â
Â